Brandt dodson biography of michael jordan

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          Volume 29, No. 2, Summer 2013

          
          Buy this back issue! Available in hardcopy or as a downloadable PDF.

          TABLE OF CONTENTS

          ARTICLES

          • The Chicago Heat Parade Keeps on Marchin’ by Jim Doherty
          • Joe Friday on Steroids: The Life and Times of Frank Ballinger, M Squad by Jim Doherty

          AUTHOR! AUTHOR!

          • Shaking Chicago by Robert P. Bennett
          • Chicago Blues by Michael Biehl
          • The Chi-Town Connection by Michael A. Black
          • Sweet Home, Chicago by Tim Chapman
          • Chicago? How Did I End Up Here? by Alan Cupp
          • The Sons of Jude by Brandt Dodson
          • Me, Chicago, and the Second Most Famous Detective in All of Fiction by Jim Doherty
          • Meet Me on Division by Barbara Fister
          • Chicago, Because It’s in My DNA by Jack Fredrickson
          • My Tenuous Chicago Connections by Kaye George
          • Chicago Doesn’t Let Go by Madeline (M.M.) Gornell
          • I Moved To Chicago for the Weather by Libby Fischer Hellmann
          • Chicago—Near Future and Noir: Walking Shadow by Clifford Royal Johns
          • Chi-hago by Kylie Logan
          • Mobster Chicago Used as the Colorful Back Story by Ed Lynskey
          • We Chicagoans by Diane Gilbert Madsen
          • Chicago at the Racetrack by John McEvoy
          • Excavating Chicago for Mysteries by Frances McNamara
          • When Real Life Serves as an Inspiration by Catherine O’Connell
          • Str

            •

            Abstract

            PTEN-induced putative kinase 1 (Pink1) is a recently identified gene linked to a recessive form of familial Parkinson's disease (PD). The kinase contains a mitochondrial localization sequence and is reported to reside, at least in part, in mitochondria. However, neither the manner by which the loss of Pink1 contributes to dopamine neuron loss nor its impact on mitochondrial function and relevance to death is clear. Here, we report that depletion of Pink1 by RNAi increased neuronal toxicity induced by MPP⁺. Moreover, wild-type Pink1, but not the G309D mutant linked to familial PD or an engineered kinase-dead mutant K219M, protects neurons against MPTP both in vitro and in vivo. Intriguingly, a mutant that contains a deletion of the putative mitochondrial-targeting motif was targeted to the cytoplasm but still provided protection against 1-methyl-4-phenylpyridine (MPP⁺)/1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced toxicity. In addition, we also show that endogenous Pink1 is localized to cytosolic as well as mitochondrial fractions. Thus, our findings indicate that Pink1 plays a functional role in the survival of neurons and that cytoplasmic targets, in addition to its other actions in the mitochondria, may be important for this protective effect.

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