Hadar busia-singleton biography of rory
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Archives West Decision Aid
General Line-up: Crim, Babcock, Pullen, Sigsworth, Railsback, Shoudy, Tibbals, Brinker, Suffragist, Dean, Psychologist, McElmon, Tilley Utah Line-up: Peterson, Mortensen, Nelsen, Matesen, Nelsen, Chemist, Jamisen, Fenn, Engersoll, Madsen, Waingard
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College of Utah Line-up: Summertime, McIntyre, Naylor, Briggs, Petersen, Barker, Wartham, Sutherland, Lady, Gardner, Travers Utah Agrarian College Line-up: Jones, Proportion, Griffin, Reformer, Snow, Sour, Egbert, Laurensen, E.Brossard, H. Brossard, Peterson, Williams, Doutrie, Caine, Philosopher, Frew, Adventurer, Hendricks, Mohr. Officials: W. Hughs, Bown, D. A. Callahan
Adamson, Herb; Barker, Elwood; Bowman, Inclination W.; Brolinbroke, Bert; Faith, Rudolph; Conroy, Maurice; Cooley, Walter; Croft, Jack; Anatomist, James; Gatherer, Bert; Author, Dave; Writer, S. R.; Hendricks, C.D.; Jeffs, Armond; Kirk, Harvey; Knowles, Pedagogue B.; Leddingham, Clarence; Playwright, Claude; Maughn, Joseph; Restricted
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Characterization of a Melamino Nitroheterocycle as a Potential Lead for the Treatment of Human AfricanTrypanosomiasis
PubMed Central
Giordani, Federica; Buschini, Annamaria; Baliani, Alessandro; Kaiser, Marcel; Brun, Reto; Barrett, Michael P.; Pellacani, Claudia; Poli, Paola
2014-01-01
This paper reports an evaluation of a melamino nitroheterocycle, a potential lead for further development as an agent against human Africantrypanosomiasis (HAT). Studies on its efficacy, physicochemical and biopharmaceutical properties, and potential for toxicity are described. The compound previously had been shown to possess exceptional activity against Trypanosoma brucei in in vitro assays comparable to that of melarsoprol. Here, we demonstrate that the compound also was curative in the stringent acute mouse model T. brucei rhodesiense STIB 900 when given intraperitoneally at 40 mg/kg of body weight. Nevertheless, activity was only moderate when the oral route was used, and no cure was obtained when the compound was tested in a stage 2 rodent model of infection. Genotoxic profiling revealed that the compound induces DNA damage by a mechanism apparently independent from nitroreduction and involving the introduction of base pair substitutions (Ames test), possibly caused by oxidative damag
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They’ve been trying their best to be discreet, so forgive us if we finger Al Pacino and Beverly D’Angelo as an item. Why all the hugger-mugger? Pacino may have been trying to spare the feelings of Lyndall Hobbs, his long-suffering girlfriend. But it was obvious from the way they were steering clear of each other on Oscar night that they’re off again. (Hobbs is now in L.
A., directing a movie with Melanie Griffith. Pacino, who turns 57 next week, is in New York scouting locations for a project he’ll produce and direct.)
D’Angelo, who is 42 and has appeared in “Hair” and the “National Lampoon’s Vacation” series, has gone out with director Neil Jordan and production designer Anton Furst.
Some wonder how long the thing with Pacino will last. Over the years, he has fathered a daughter with dancer Jan Tarrant and been involved with Diane Keaton, Jill Clayburgh, Marthe Keller and Penelope Anne Miller, to name his better-known partners.
Hobbs has persevered longer than most, though after years of waiting for a commitment from Pacino, finally ended up adopting a baby boy on her own.
“Al is never going to settle down, and any woman who thinks so is crazy,” says one source. “But for now, he and Beverly are